[Formation of immune interferon in children with hemoblastoses]

Production of immune interferon by bone marrow mononuclears stimulated by phytohemagglutinin was experimentally demonstrated in vitro. The most effective dose of mitogen in this cell system was found to be 10 micrograms/ml, and the maximum gamma-interferon response was observed at 6-7 days of cultivation. At the same time, cultures of the peripheral blood mononuclears showed two peaks of antiviral activity: at 3 and 7 days. Comparison of interferon production in parallel cultures of blood and bone marrow mononuclears showed the potentials of mononuclears from both systems to be similar despite obvious heterogeneity of the cell composition of lymphoid cell populations.