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Related Experiment Videos

Inhibition of platelet function by injectable isosorbide dinitrate.

R De Caterina, D Giannessi, F Crea

    The American Journal of Cardiology
    |June 1, 1984
    PubMed
    Summary

    Isosorbide dinitrate (ISDN) inhibits human platelet function in vitro and in vivo. Lower doses show antiplatelet effects, but these are reduced with higher doses causing significant hemodynamic changes.

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    Area of Science:

    • Pharmacology
    • Cardiovascular Medicine
    • Hematology

    Background:

    • Platelet aggregation plays a crucial role in thrombosis.
    • Isosorbide dinitrate (ISDN) is a vasodilator used for angina.
    • The antiplatelet effects of ISDN require further investigation.

    Purpose of the Study:

    • To investigate the in vitro and in vivo effects of isosorbide dinitrate (ISDN) on human platelet function.
    • To determine the relationship between ISDN dosage, hemodynamic effects, and antiplatelet activity.

    Main Methods:

    • Platelet-rich plasma from healthy subjects was incubated with ISDN in vitro.
    • Platelet aggregation was induced by ADP, adrenaline, and arachidonic acid.
    • ISDN was infused intravenously in patients with angina at two different rates.

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  • Circulating platelet aggregates and hemodynamic parameters were monitored.

    • Main Results:

    • In vitro, high ISDN concentrations significantly reduced platelet aggregation and thromboxane B2 generation.
    • In vivo, a lower ISDN infusion rate significantly decreased ADP- and adrenaline-induced platelet aggregation and circulating platelet aggregates.
    • Higher ISDN infusion rates causing marked hemodynamic effects did not show clear antiplatelet effects.
    • In vivo antiplatelet effects occurred at lower concentrations than in vitro.

    Conclusions:

    • Isosorbide dinitrate (ISDN) demonstrates antiplatelet activity both in vitro and in vivo.
    • The antiplatelet effects of ISDN are dose-dependent and can be influenced by concurrent hemodynamic changes.
    • Lower doses of ISDN may offer therapeutic benefits by modulating platelet function without significant hemodynamic compromise.