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Abstract:
Presented is the case of a 42-year-old, previously healthy man with meningitis secondary to Listeria monocytogenes. Following lumbar puncture, empiric therapy with intravenous penicillin was started and he was hospitalized. Subsequently L monocytogenes was proven to be the causative organism and antibiotic therapy was changed to ampicillin and gentamicin. The patient's condition improved. He was discharged and continues to do well. There was no evidence at any time of underlying predisposition to infection. Listeria meningitis in healthy patients and in patients with underlying disease is discussed, along with possible implications about choice of empiric antibiotics.
Insights
This case study highlights a healthy adult successfully treated for Listeria monocytogenes meningitis. Prompt diagnosis and appropriate antibiotic therapy led to a full recovery, emphasizing effective treatment strategies for this infection.
Area of Science:
- Infectious Diseases
- Neurology
- Microbiology
Background:
- Listeria monocytogenes meningitis is a serious infection, particularly concerning in immunocompromised individuals.
- While less common, it can occur in healthy individuals, necessitating prompt recognition and treatment.
Observation:
- A previously healthy 42-year-old male presented with meningitis.
- Initial empiric treatment with intravenous penicillin was administered post-lumbar puncture.
Findings:
- Causative organism identified as Listeria monocytogenes.
- Treatment was adjusted to ampicillin and gentamicin, resulting in clinical improvement.
- The patient had no identifiable underlying predisposition to infection.
Implications:
- This case underscores the importance of considering Listeria monocytogenes in meningitis, even in healthy patients.
- Treatment strategies involving ampicillin and gentamicin appear effective.
- The findings may inform empiric antibiotic choices for suspected bacterial meningitis.