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Published on: July 21, 2017
Diminished plasma free fatty acid clearance in obese subjects
Metabolism: Clinical and Experimental
|May 1, 1978
Summary
Obesity impairs the body's ability to clear free fatty acids (FFA), affecting fat metabolism. This reduced FFA clearance in obese individuals is linked to impaired fat metabolism, even with insulin stimulation.
Area of Science:
- Metabolic Research
- Obesity Studies
- Fatty Acid Metabolism
Background:
- Disturbances in plasma free fatty acid (FFA) kinetics are reported in obese individuals.
- Understanding whether these disturbances involve altered FFA transport (lipolysis) or clearance (esterification) is crucial.
Purpose of the Study:
- To compare FFA kinetics in obese versus lean subjects.
- To define the specific mechanisms of FFA metabolism disturbance in obesity.
Main Methods:
- Infusion of 1--14C-palmitate in obese and lean subjects during and after glucose ingestion.
- Measurement of net transport (lipolysis) and clearance (esterification) of plasma FFA.
Main Results:
- Net FFA transport was suppressed in both groups, requiring higher insulin in obese subjects.
- FFA clearance was stimulated by glucose in lean but remained low in obese subjects.
- FFA influx increased post-glucose more in some obese than lean subjects, raising plasma triglycerides only in lean subjects.
Conclusions:
- Clearance of plasma FFA (likely tissue esterification) is impaired in obesity and poorly responsive to glucose and insulin.
- Lipolysis (net FFA transport) is suppressible in obese individuals, but requires higher insulin levels than in lean subjects.
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