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[Magnesium deficiencies in cardiovascular diseases].

L Guize, J Y Le Heuzey, D Blanchard

    Archives Des Maladies Du Coeur Et Des Vaisseaux
    |April 1, 1984
    PubMed
    Summary
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    Magnesium depletion is linked to various cardiovascular conditions like mitral valve prolapse and coronary insufficiency. Further research is needed to understand magnesium

    Area of Science:

    • Cardiology
    • Clinical Biochemistry
    • Mineral Metabolism

    Background:

    • Magnesium is crucial for cardiovascular function.
    • Low magnesium levels have been anecdotally linked to cardiovascular diseases.

    Purpose of the Study:

    • To investigate plasma (pl) and red blood cell (ery) magnesium (Mg) concentrations in patients with cardiovascular conditions.
    • To compare Mg levels in patients with specific cardiovascular diseases against a control group.

    Main Methods:

    • Spectrophotometry was used to measure pl, ery, and urinary Mg.
    • Simultaneous measurement of pl and ery potassium, calcium, and phosphate.
    • Study included over 300 patients and 54 controls.

    Main Results:

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    • Significant magnesium depletion was observed in patients with mitral valve prolapse, recurrent junctional tachycardia, coronary insufficiency, and hypertension.
    • Mg deficits were more pronounced in women with mitral valve prolapse.
    • Low Mg levels were sometimes associated with low calcium and low red blood cell potassium.

    Conclusions:

    • Magnesium depletion is prevalent in several cardiovascular conditions.
    • The precise role of magnesium depletion in cardiovascular disease pathogenesis requires further investigation.
    • Intravenous magnesium repletion showed benefit in some cases but did not alter plasma concentrations.