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Shape changes in goose erythrocytes.

M Nikinmaa, W H Huestis

    Biochimica Et Biophysica Acta
    |June 27, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Goose red blood cells showed distinct responses to echinocytosis-inducing agents. Unlike human cells, goose erythrocytes developed membrane wrinkles or sphericity depending on the specific treatment, revealing species-specific erythrocyte morphology changes.

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    Area of Science:

    • Cell Biology
    • Hematology
    • Biochemistry

    Background:

    • Erythrocyte morphology is crucial for red blood cell function.
    • Echinocytosis, a shape change in red blood cells, can be induced by various agents in human erythrocytes.
    • Investigating echinocytosis in non-human erythrocytes provides insights into conserved and divergent cellular mechanisms.

    Purpose of the Study:

    • To investigate the effects of agents known to induce echinocytosis in human erythrocytes on goose erythrocytes.
    • To characterize the morphological changes in goose red blood cells under different experimental conditions.

    Main Methods:

    • Goose erythrocytes were treated with the ionophore A23187 and calcium.
    • Metabolic nucleoside triphosphate (NTP) depletion was induced using iodoacetamide or substrate deprivation.

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  • Cells were also exposed to echinocytic agents indomethacin and dimyristoylphosphatidylcholine.
  • Morphological changes were observed using microscopy.

    • Main Results:

    • Treatment with A23187 and calcium induced semiregular membrane wrinkles (corrugations) in goose erythrocytes.
    • Metabolic NTP depletion initially caused similar corrugations, progressing to spherical cells with peripheral nuclei upon prolonged incubation.
    • Indomethacin and dimyristoylphosphatidylcholine did not alter the gross morphology of goose erythrocytes.

    Conclusions:

    • Goose erythrocytes exhibit differential responses to echinocytosis-inducing agents compared to human erythrocytes.
    • Calcium and ionophore A23187 induce a unique corrugated morphology in goose red blood cells.
    • Metabolic stress leads to distinct shape changes, including sphericity, in goose erythrocytes, highlighting species-specific cellular adaptations.