The effects of acute carbaryl exposure on clotting factor activity in the rat

Male Sprague-Dawley rats were placed on a drinking solution containing either 10 parts per million (ppm) carbaryl or water for 30 days. Plasma was analyzed for the prothrombin time, partial thromboplastin time, fibrinogen, and clotting factor activity for coagulation factors II, V, VII, VIII, IX, X, XII and the platelet count. Only two hematological parameters measured were statistically different from the controls; these parameters were the platelet count and factor VII activity, both of which were reduced. Histological examination of the hepatic tissue illustrated that a number of pathological changes were occurring.