Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

1.2K
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
1.2K
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

1.0K
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
1.0K
Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

807
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
807
Peptic Ulcer01:27

Peptic Ulcer

48
Peptic ulcers are erosive lesions of the gastric or duodenal lining, most commonly caused by Helicobacter pylori infection. This Gram-negative, helical bacterium has adapted to survive the stomach’s acidic environment by producing urease, which converts urea into ammonia and carbon dioxide. The ammonia neutralizes gastric acid in the bacterium’s immediate environment, allowing colonization of the gastric mucosa. H. pylori attaches to mucus-secreting epithelial cells, penetrates the...
48
Peptic Ulcer Disease I: Introduction01:25

Peptic Ulcer Disease I: Introduction

28
Peptic ulcer disease (PUD) involves breaks in the gastrointestinal tract's mucosal lining, primarily in the stomach and duodenum, with less frequent occurrences in the lower esophagus or near the pylorus.Ulcers can be acute or chronic. Acute ulcers are short-lived with minimal inflammation and heal quickly after the irritant is removed. Chronic ulcers persist, may recur, and often cause scarring due to ongoing tissue damage. Superficial erosions affect only the mucosal layer and are called...
28
Peptic Ulcer Disease III: Clinical Manifestations and Complications01:25

Peptic Ulcer Disease III: Clinical Manifestations and Complications

38
Duodenal UlcersDuodenal ulcers are the most common form of peptic ulcer disease, presenting with chronic, intermittent epigastric pain. Pain typically appears 2–3 hours after meals, especially when the stomach is empty, often waking patients at night. It is characteristically relieved by food or antacids (“pain–food–relief”). Some patients remain asymptomatic until complications like bleeding or perforation emerge, particularly with NSAID or anticoagulant...
38

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Omeprazole or ranitidine for reflux oesophagi tis.

The National medical journal of India·2018
Same author

Will omeprazole succeed in refractory duodenal ulcer when the histamine receptor antagonists fail?

The National medical journal of India·2018
Same author

Faecal calprotectin for differentiating between irritable bowel syndrome and inflammatory bowel disease: a useful screen in daily gastroenterology practice.

Frontline gastroenterology·2017
Same author

Breathomics--exhaled volatile organic compound analysis to detect hepatic encephalopathy: a pilot study.

Journal of breath research·2016
Same author

Development and application of a new electronic nose instrument for the detection of colorectal cancer.

Biosensors & bioelectronics·2014
Same author

The scars of time: the disappearance of peptic ulcer-related pyloric stenosis through the 20th century.

The journal of the Royal College of Physicians of Edinburgh·2014

Related Experiment Video

Updated: May 5, 2026

Robotic D3 Partial Duodenal Resection with Primary Side-to-Side Anastomosis
10:41

Robotic D3 Partial Duodenal Resection with Primary Side-to-Side Anastomosis

Published on: December 15, 2023

3.4K

Refractory duodenal ulcer.

K D Bardhan

    Gut
    |July 1, 1984
    PubMed
    Summary

    Refractory duodenal ulcers resist standard treatment. Increasing cimetidine dosage aided healing in some, but optimal management for these difficult ulcers remains undetermined.

    Area of Science:

    • Gastroenterology
    • Pharmacology

    Background:

    • Refractory duodenal ulcers are defined as those not healing after three months of standard cimetidine treatment.
    • These ulcers present diagnostic and management challenges in clinical practice.

    Purpose of the Study:

    • To investigate the characteristics and treatment outcomes of refractory duodenal ulcers.
    • To explore potential factors influencing ulcer refractoriness and assess surgical outcomes.

    Main Methods:

    • A cohort of 66 patients with refractory duodenal ulcers was studied.
    • Treatment involved standard or increased doses of cimetidine, with some patients undergoing surgery.

    Main Results:

    • Healing occurred in 37 of 66 patients after extended treatment (average 7.4 months).

    More Related Videos

    Application of Robot-assisted Pancreaticobiliary Junction Resection in Benign Duodenal Tumors
    03:37

    Application of Robot-assisted Pancreaticobiliary Junction Resection in Benign Duodenal Tumors

    Published on: December 20, 2024

    1.0K
    Robotic Duodenum-preserving Total Pancreatic Head Resection for Intraductal Papillary Mucinous Neoplasms
    10:10

    Robotic Duodenum-preserving Total Pancreatic Head Resection for Intraductal Papillary Mucinous Neoplasms

    Published on: April 17, 2026

    200

    Related Experiment Videos

    Last Updated: May 5, 2026

    Robotic D3 Partial Duodenal Resection with Primary Side-to-Side Anastomosis
    10:41

    Robotic D3 Partial Duodenal Resection with Primary Side-to-Side Anastomosis

    Published on: December 15, 2023

    3.4K
    Application of Robot-assisted Pancreaticobiliary Junction Resection in Benign Duodenal Tumors
    03:37

    Application of Robot-assisted Pancreaticobiliary Junction Resection in Benign Duodenal Tumors

    Published on: December 20, 2024

    1.0K
    Robotic Duodenum-preserving Total Pancreatic Head Resection for Intraductal Papillary Mucinous Neoplasms
    10:10

    Robotic Duodenum-preserving Total Pancreatic Head Resection for Intraductal Papillary Mucinous Neoplasms

    Published on: April 17, 2026

    200
  • Increasing cimetidine dosage to 2g or 3g daily improved healing rates in some patients.
  • Eighteen patients required hospitalization for severe symptoms, and five of nine surgical cases had poor outcomes.

    • Conclusions:

    • Identifying refractory ulcer patients at the outset is not possible based on clinical, endoscopic, or biochemical factors.
    • The cause of cimetidine refractoriness is unknown, and surgical outcomes are suboptimal.
    • Refractory ulcers may indicate a changed disease natural history with a poorer prognosis, requiring further research into optimal management strategies.