Related Experiment Videos
Safety and efficacy of 2% methylcellulose in cat and monkey cataract-implant surgery
Abstract:
We evaluated the safety and efficacy of 2% methycellulose as an adjunct for cataract extraction with implantation in cat and monkey models. When used intraoperatively, methylcellulose reduced the iridovitreal bulge during surgery. No significant increase in clinical inflammation occurred nor was there statistically significant intraocular pressure elevation at 24 hours, 7 days, or 90 days. In the cat model, the central corneal thickness increased at day seven in both control and methylcellulose eyes; this thickness persisted to 90 days. The endothelial cell loss decreased significantly at day 90 in methylcellulose eyes. In the monkey model, no statistically significant increase in corneal thickness occurred in control or methylcellulose eyes at day seven. The endothelial cell loss was greater than in the cat model in both control and methylcellulose eyes; there was no statistically significant difference between the two. Two percent methylcellulose was safe in both the cat and monkey models. It facilitated surgery in both models and reduced the endothelial cell loss in the cat eye.
Insights
Two percent methylcellulose is safe and effective for cataract surgery in cats and monkeys. This ophthalmic solution facilitated surgery and reduced endothelial cell loss in cats.
Area of Science:
- Ophthalmology
- Veterinary Medicine
- Biomaterials
Background:
- Cataract surgery requires intraoperative aids to maintain ocular structures.
- Methylcellulose is a viscoelastic agent used in ophthalmic procedures.
Purpose of the Study:
- To evaluate the safety and efficacy of 2% methylcellulose as an adjunct in cataract extraction with intraocular lens implantation.
- To assess the impact of methylcellulose on intraocular pressure, inflammation, corneal thickness, and endothelial cell loss in feline and primate models.
Main Methods:
- Surgical procedures were performed on cat and monkey models with and without 2% methylcellulose.
- Intraocular pressure, clinical inflammation, corneal thickness, and endothelial cell counts were monitored postoperatively at various time points (24 hours, 7 days, 90 days).
Main Results:
- Methylcellulose reduced iridovitreal bulge during surgery.
- No significant increase in clinical inflammation or intraocular pressure was observed.
- In cats, methylcellulose reduced endothelial cell loss at 90 days, though corneal thickness increased transiently.
- In monkeys, no significant corneal thickness increase occurred, and endothelial cell loss was not significantly different between groups.
Conclusions:
- Two percent methylcellulose is safe for use in feline and primate eyes during cataract surgery.
- It serves as an effective surgical adjunct, facilitating the procedure.
- Methylcellulose demonstrated a significant benefit in reducing endothelial cell loss in the cat model.