Effects of a benzodiazepine antagonist on the diazepam-induced electrical brain activity modifications

Brain electrical activity changes induced by Ro 15-1788, an antagonist of central benzodiazepine effects, were investigated in 10 normal subjects. The diazepam-induced sedation, as ascertained by spontaneous EEG, was rapidly reversed after an intravenous injection of 5 mg Ro 15-1788. There appeared to be a good correlation between the EEG and evoked responses modifications; the decrease of the amplitude of the N2 wave may reflect an increase of alertness.