Ultrastructure of human eosinophils genetically lacking peroxidase

The structure of human eosinophils genetically lacking peroxidase is described. Structural changes were discerned in the specific granules of the deficient eosinophils as compared to normal eosinophils. Apart from the inhibition of peroxidase formation, this mutation also affects the structure of the specific granules - primarily the interrelationship between the matrix and the core.