Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mathematical modeling and numerical solutions for functionally dependent bone remodeling.

R T Hart, D T Davy, K G Heiple

    Calcified Tissue International
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A homoleptic chromium(iii) carboxylate.

    Dalton transactions (Cambridge, England : 2003)·2018
    Same author

    Plasma surface modification of electrospun fibers for adhesion-based cancer cell sorting.

    Integrative biology : quantitative biosciences from nano to macro·2012
    Same author

    A new synthesis of 1,2-benzanthracene.

    Journal of the American Chemical Society·2010
    Same author

    Local bone formation due to combined mechanical loading and intermittent hPTH-(1-34) treatment and its correlation to mechanical signal distributions.

    Journal of biomechanics·2009
    Same author

    Isolated traumatic dislocation of the distal end of the ulna or distal radio-ulnar joint.

    The Journal of bone and joint surgery. American volume·2009
    Same author

    A cellular solid model of the lamina cribrosa: mechanical dependence on morphology.

    Journal of biomechanical engineering·2006
    Same journal

    Capsanthin Attenuates Osteoporosis by Targeting the Urotensin II Receptor Pathway to Inhibit Oxidative Stress and NLRP3 Inflammasome Activation.

    Calcified tissue international·2026
    Same journal

    ODAPH (p.Arg77*) Phenotype and Onset of Ameloblast Pathology During Postsecretory Transition Demonstrated by FIB-SEM Analyses of Odaph<sup>C41*/C41*</sup> Mice.

    Calcified tissue international·2026
    Same journal

    Cytokine Networks Reprogramming the Osteo-Immune Microenvironment in Cancer Bone Metastasis.

    Calcified tissue international·2026
    Same journal

    Associations between controlling nutritional status and mortality in osteoporosis: evidence from NHANES, 2005-2018.

    Calcified tissue international·2026
    Same journal

    Gut Microbiota-Derived TMAO Drives MC3T3-E1 Senescence and Osteogenic Dysfunction via cGAS-STING-NF-κB Signaling: Implications for Age-Related Bone Loss.

    Calcified tissue international·2026
    Same journal

    Artificial Intelligence Approaches for Osteoporotic Fracture Risk Prediction Using Administrative Health Data: A Systematic Review.

    Calcified tissue international·2026
    See all related articles

    This study presents a mathematical model for bone remodeling, predicting adaptive bone responses to mechanical load. The model accounts for biological factors and uses a numerical procedure to simulate changes in bone structure over time.

    Area of Science:

    • Biomechanical Engineering
    • Computational Biology
    • Orthopedic Research

    Background:

    • Bone remodeling is a complex biological process influenced by genetic, hormonal, metabolic, age, and functional factors.
    • Understanding the transducer that senses functional requirements is key to predicting bone's adaptive response to load.
    • Current knowledge limitations hinder precise modeling of bone remodeling's functional dependence.

    Purpose of the Study:

    • To develop a phenomenological mathematical model for bone remodeling.
    • To relate model parameters to biological variables for enhanced interpretability.
    • To create a numerical procedure for predicting and simulating bone's adaptive structural changes.

    Main Methods:

    • Developed a phenomenological model assuming a 'remodeling potential' modulated by biological factors.

    Related Experiment Videos

  • Formulated mathematical equations with parameters linked to biological entities.
  • Implemented a numerical procedure to calculate strain distribution, predict remodeling based on strain history, and update bone geometry and material properties iteratively.

    • Main Results:

    • The developed model provides a framework for predicting bone's adaptive response to mechanical loading.
    • The numerical procedure allows for the simulation of structural changes in bone architecture over time.
    • The approach accommodates complex geometries, material distributions, and anisotropic properties.

    Conclusions:

    • The phenomenological model and numerical procedure offer a valuable tool for studying bone adaptation.
    • This framework can be applied to irregular geometries and complex material properties in bone modeling.
    • Further research into the specific transducer mechanisms will enhance predictive accuracy.