Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nitrate tolerance.

J O Parker

    Herz
    |June 1, 1984
    PubMed
    Summary

    Tolerance to isosorbide dinitrate develops rapidly within 24 hours but is quickly reversed upon withdrawal. Sublingual nitrates can restore exercise performance even with oral tolerance.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    ARCTIC: assessment of haemodynamic response in patients with congestive heart failure to telmisartan: a multicentre dose-ranging study in Canada.

    American heart journal·1999
    Same author

    Congenital arteriovenous fistula of internal thoracic artery: successfully managed by transcatheter embolization.

    Catheterization and cardiovascular diagnosis·1998
    Same author

    Nitrate therapy for stable angina pectoris.

    The New England journal of medicine·1998
    Same author

    Cardiovascular death and left ventricular remodeling two years after myocardial infarction: baseline predictors and impact of long-term use of captopril: information from the Survival and Ventricular Enlargement (SAVE) trial.

    Circulation·1997
    Same author

    The effect of hydralazine on the development of tolerance to continuous nitroglycerin.

    The Journal of pharmacology and experimental therapeutics·1997
    Same author

    Nitrate tolerance--problems both new and old.

    The Canadian journal of cardiology·1996

    Area of Science:

    • Pharmacology
    • Cardiovascular Medicine

    Background:

    • Nitrate vasodilators like isosorbide dinitrate are crucial for managing angina.
    • Understanding nitrate tolerance is essential for optimizing antianginal therapy.

    Purpose of the Study:

    • To investigate the development and reversal of tolerance to isosorbide dinitrate's hemodynamic and antianginal effects.
    • To examine cross-tolerance between isosorbide dinitrate and nitroglycerin.

    Main Methods:

    • Studies assessed hemodynamic responses and exercise performance following nitrate administration.
    • Tolerance was evaluated by repeated dosing and withdrawal periods.

    Main Results:

    • Rapid tolerance to isosorbide dinitrate's effects occurs within 24 hours.
    • Tolerance reverses within 21 hours of drug withdrawal.
    • Cross-tolerance exists between isosorbide dinitrate and nitroglycerin.
    • Sublingual nitrates improve exercise capacity despite oral isosorbide dinitrate tolerance.

    Conclusions:

    • Nitrate tolerance is a significant clinical consideration.
    • Rapid reversibility suggests intermittent dosing strategies may be viable.
    • Sublingual administration offers an alternative route to overcome oral tolerance.

    Related Experiment Videos