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Injectable copper and tissue composition of cattle.

V R Bohman, E L Drake, W C Behrens

    Journal of Dairy Science
    |July 1, 1984
    PubMed
    Summary

    Copper edetate and glycinate forms show distinct initial plasma copper levels in calves. Copper edetate leads to less tissue irritation, with rapid liver storage minimizing toxic blood copper concentrations.

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    Area of Science:

    • Veterinary Medicine
    • Animal Nutrition
    • Biochemistry

    Background:

    • Understanding copper metabolism is crucial for cattle health and productivity.
    • Different copper salt formulations may influence bioavailability and tissue response.
    • Assessing the safety and efficacy of supplemental copper sources is important.

    Purpose of the Study:

    • To compare the effects of copper salts of glycine and edetate on blood plasma and liver copper concentrations in cattle.
    • To evaluate tissue reactions and potential toxicity associated with different copper formulations.
    • To investigate the absorption, distribution, and storage patterns of injected copper.

    Main Methods:

    • Holstein calves were injected with varying doses of copper salts of glycine or edetate.
    • Blood plasma copper concentrations were measured at multiple time points post-injection.
    • Liver tissue was analyzed for copper storage, and local tissue reactions were assessed.

    Main Results:

    • Initially, copper edetate resulted in higher plasma copper concentrations compared to copper glycinate.
    • These differences were most pronounced within the first 24 hours post-injection.
    • Copper edetate caused less subcutaneous tissue irritation, although severe hemolysis was observed with high doses of copper edetate without mortality.

    Conclusions:

    • Injected copper, particularly copper edetate, is rapidly mobilized from injection sites.
    • Copper is quickly stored in the liver, which likely prevents toxic elevations in blood copper levels.
    • Copper edetate appears to be a viable alternative with potentially reduced local tissue reactions compared to copper glycinate.

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