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Related Experiment Videos

Sleep pattern alterations by naloxone. Partial prevention by haloperidol.

C Cianchetti, C Masala, P Olivari

    Psychopharmacology
    |January 1, 1984
    PubMed
    Summary
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    Naloxone, an opiate receptor antagonist, reduced REM and stage 4 sleep in normal subjects. Dopamine receptor stimulation partially mediates this effect, as shown by haloperidol pretreatment.

    Area of Science:

    • Neuroscience
    • Sleep Medicine
    • Pharmacology

    Background:

    • Opiate receptors play a role in regulating sleep architecture.
    • The interaction between opiate and dopamine systems in sleep is not fully understood.

    Purpose of the Study:

    • To investigate the effects of naloxone, an opiate receptor antagonist, on sleep stages in healthy adults.
    • To explore the potential involvement of dopamine receptors in naloxone's effects on sleep.

    Main Methods:

    • Continuous intravenous infusion of naloxone (0.7-1.0 µg/kg/min) in eight healthy subjects during the first 240 minutes of nocturnal sleep.
    • Administration of haloperidol (2 mg IM) prior to sleep onset in a subset of trials to assess dopamine receptor involvement.

    Main Results:

    Related Experiment Videos

    • Naloxone administration resulted in a significant reduction in the duration of REM sleep and stage 4 sleep.
    • Pretreatment with haloperidol partially attenuated the sleep-altering effects of naloxone.

    Conclusions:

    • Opiate receptor antagonism by naloxone influences sleep architecture, specifically reducing REM and stage 4 sleep.
    • Dopamine receptor stimulation appears to be partially involved in mediating the observed effects of naloxone on sleep patterns.