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[Enzymatic lipid peroxidation].

V Z Lankin

    Ukrainskii Biokhimicheskii Zhurnal (1978)
    |May 1, 1984
    PubMed
    Summary

    Enzymatic lipid peroxidation, involving cyclooxygenases and lipoxygenases, is more active than non-enzymatic processes. Cytosol lipoxygenase may alter its function and product profile when dissociating from enzyme complexes.

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    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Cellular Physiology

    Background:

    • Biologically active substances like prostaglandins and leukotrienes are synthesized via lipid peroxidation.
    • Enzymatic lipid peroxidation by microsomal dioxygenases is more active than non-enzymatic processes in animal tissues.
    • Distinct molecular structures arise from enzymatic versus non-enzymatic lipid peroxidation products.

    Purpose of the Study:

    • To investigate the role and behavior of lipoxygenase in lipid peroxidation.
    • To explore the relationship between cytosol lipoxygenase and the cyclooxygenase multienzymic complex.
    • To understand how enzyme conformation changes affect the products of polyenic lipid oxidation.

    Main Methods:

    • Comparative analysis of enzymatic and non-enzymatic lipid peroxidation.
    • Investigation of microsomal dioxygenase activity.
    • Hypothesizing the role of cytosol lipoxygenase as a dissociable component.

    Main Results:

    • Enzymatic lipid peroxidation is significantly more active than non-enzymatic in comparable membrane structures.
    • The molecular structures of products from enzymatic and non-enzymatic lipid peroxidation differ substantially.
    • Cytosol lipoxygenase is proposed as a potentially dissociable component of the cyclooxygenase complex.

    Conclusions:

    • Cytosol lipoxygenase may detach from the cyclooxygenase complex, altering its conformation.
    • This detachment leads to changes in the chemical nature of oxidized polyenic lipids.
    • Understanding these enzymatic dynamics is crucial for comprehending lipid-mediated signaling pathways.

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