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Malignant catarrhal fever.

H W Reid, D Buxton, E Berrie

    The Veterinary Record
    |June 16, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Malignant catarrhal fever (MCF) in deer is caused by a herpesvirus. Recent studies in rabbits reveal MCF pathogenesis involves T-lymphocyte and natural killer cell deregulation, leading to tissue damage.

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    Prefatory Note and Explanations.

    Glasgow medical journal·2018

    Area of Science:

    • Veterinary Virology
    • Immunology
    • Pathology

    Background:

    • Malignant catarrhal fever (MCF) is a severe disease affecting cattle and deer.
    • Historically, 'sheep-associated' MCF in Europe lacked a known cause, while African MCF was linked to a wildebeest herpesvirus.
    • Deer exhibit high susceptibility to both MCF forms, posing significant challenges in farmed deer populations.

    Purpose of the Study:

    • To review malignant catarrhal fever (MCF) and present recent findings on its pathogenesis.
    • To describe the clinical and pathological changes observed in deer affected by MCF.
    • To summarize new insights into MCF pathogenesis enabled by a novel experimental model.

    Main Methods:

    • Review of existing literature on malignant catarrhal fever (MCF).

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  • Description of clinical and pathological findings in naturally infected deer.
  • Transmission of MCF from deer to rabbits to establish an experimental laboratory system for pathogenesis studies.

    • Main Results:

    • Deer are highly susceptible to both sheep-associated and wildebeest-associated MCF.
    • A rabbit model was successfully established, facilitating detailed pathogenesis studies.
    • MCF pathogenesis is suggested to involve a specific T-lymphocyte subpopulation infection, leading to immunological perturbation.

    Conclusions:

    • The agent of sheep-associated MCF is likely a virus.
    • MCF pathogenesis involves T-lymphocyte hyperplasia and deregulation of cytotoxic natural killer lymphocytes.
    • These immunological disruptions explain the characteristic tissue necrosis observed in malignant catarrhal fever.