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[Epileptic seizures in multiple sclerosis patients].

I A Zavalishin, O M Nevskaia

    Zhurnal Nevropatologii I Psikhiatrii Imeni S.S. Korsakova (Moscow, Russia : 1952)
    |January 1, 1984
    PubMed
    Summary

    Epileptic seizures occurred in 1.5% of multiple sclerosis patients, often signaling active disease. Immunological factors are implicated in seizure development during multiple sclerosis exacerbations.

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    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2013

    Area of Science:

    • Neurology
    • Immunology
    • Neuroimmunology

    Context:

    • Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
    • Epileptic seizures are a recognized, though not universal, clinical manifestation in MS patients.
    • Understanding seizure triggers and indicators is crucial for managing MS progression.

    Purpose:

    • To investigate the occurrence and significance of epileptic seizures in a cohort of multiple sclerosis patients.
    • To determine if seizure frequency correlates with disease activity or exacerbation.
    • To explore the role of immunological impairments in the pathogenesis of MS-related seizures.

    Summary:

    • Epileptic seizures were observed in 12 out of 800 (1.5%) patients with multiple sclerosis.
    • Seizure occurrence was notably higher during periods of disease exacerbation.
    • These seizures are suggested to be an indicator of underlying pathological process activity in MS.

    Impact:

    • Highlights epileptic seizures as a potential clinical marker for active multiple sclerosis.
    • Underscores the importance of considering immunological factors in MS-related epilepsy.
    • Informs clinical practice regarding seizure monitoring and management in multiple sclerosis patients.

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