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Decrease in rate of wound contraction with the temporary skin substitute biobrane.

D H Frank, J Brahme, J S Van de Berg

    Annals of Plastic Surgery
    |June 1, 1984
    PubMed
    Summary
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    Biobrane, a synthetic skin substitute, significantly reduces wound contraction in burn patients by threefold. This finding offers new insights into preventing contracture deformities after severe burns.

    Area of Science:

    • Biomedical Engineering
    • Wound Healing Research
    • Regenerative Medicine

    Background:

    • Normal wound healing in burn patients can lead to contracture deformities, necessitating further reconstructive surgery.
    • Full-thickness skin grafts are known to inhibit wound contraction and myofibroblast activity, though the mechanism remains unclear.
    • Biobrane, a temporary synthetic skin substitute, is a viable alternative to cadaver allografts for various wounds.

    Purpose of the Study:

    • To investigate the potential of Biobrane to inhibit wound contraction.
    • To compare the efficacy of Biobrane in preventing wound contraction versus open wound healing.

    Main Methods:

    • A comparative study was conducted on 20 rats with surgically created wounds.
    • Wounds were either left open or covered with Biobrane.

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  • Wound size was measured over time, and linear regression analysis was used to determine contraction rates.

    • Main Results:

    • A statistically significant reduction in wound size was observed in Biobrane-covered wounds compared to open wounds (p < 0.005).
    • Linear regression analysis revealed a threefold decrease in the rate of wound contraction with Biobrane adherence.
    • The inhibitory effect was noted during the period Biobrane remained attached to the wound.

    Conclusions:

    • Biobrane demonstrates a significant capacity to inhibit wound contraction in a preclinical model.
    • The findings suggest Biobrane may be a valuable tool in preventing contracture deformities in burn patients.
    • Further research is warranted to elucidate the precise mechanisms of Biobrane's inhibitory action, potentially involving mechanical stenting or direct myofibroblast inhibition.