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[Left ventricular global and segmental function in pure mitral valve prolapse with poor tolerance for exertion]
Archives Des Maladies Du Coeur Et Des Vaisseaux
|June 1, 1984
Summary
Idiopathic mitral valve prolapse (IMVP) can cause poor effort tolerance due to abnormal left ventricular function. This study found impaired wall motion and compliance in IMVP patients, affecting the antero-lateral wall.
Area of Science:
- Cardiology
- Cardiac Physiology
Background:
- Idiopathic mitral valve prolapse (IMVP) can present with poor effort tolerance in some individuals.
- The underlying cause of this reduced exercise capacity in IMVP is not fully understood.
Purpose of the Study:
- To investigate potential left ventricular (LV) dysfunction contributing to poor effort tolerance in patients with IMVP.
- To analyze global and regional LV function, including segmental wall motion, in IMVP patients.
Main Methods:
- Retrospective analysis of 17 IMVP patients and 21 controls using cardiac catheterization and RAO left ventriculography.
- Quantitative assessment of LV global function (systolic/diastolic parameters, volumes) and regional wall motion using an adapted Stanford method.
- Analysis of contraction and relaxation timing and velocity of LV segments.
Main Results:
- IMVP patients exhibited abnormal LV volumic compliance and regional wall motion compared to controls.
- Asynergy was primarily localized to the antero-lateral wall of the LV.
- While contraction amplitude was often normal, it occurred slower and finished earlier, with abnormally early and prolonged relaxation in the affected zone.
Conclusions:
- Left ventricular dysfunction, characterized by impaired compliance and altered regional wall motion (asynergy), is present in IMVP patients with poor effort tolerance.
- The specific pattern of altered contraction and relaxation in the antero-lateral wall suggests a localized functional abnormality contributing to symptoms.