Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cluster analysis of genes in codon space.

G W Rowe, V L Szabo, L E Trainor

    Journal of Molecular Evolution
    |January 1, 1984
    PubMed
    Summary

    DNA base composition varies nonrandomly across codon positions, correlating with organismal evolution. Primitive organisms show higher A/T content, while complex organisms exhibit increased G/C content, revealing evolutionary patterns.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Coronary computed tomography--present status and future directions.

    International journal of clinical practice. Supplement·2011
    Same author

    Two-category model of task allocation with application to ant societies.

    Bulletin of mathematical biology·2001
    Same author

    A stochastic evolutionary model of molecular sequences.

    Journal of theoretical biology·1992
    Same author

    Geometrical aspects of surface morphogenesis.

    Journal of theoretical biology·1989
    Same author

    Diffusion effects in calcium-regulated strain fields.

    Journal of theoretical biology·1989
    Same author

    To each genotype a separate strategy--a dynamic game theory model of a general diploid system.

    Journal of theoretical biology·1988

    Area of Science:

    • Genomics
    • Molecular Biology
    • Bioinformatics

    Background:

    • DNA sequences exhibit base composition patterns.
    • Understanding these patterns can reveal evolutionary relationships.

    Purpose of the Study:

    • To analyze DNA base composition across codon positions.
    • To correlate these patterns with organismal evolutionary complexity.

    Main Methods:

    • Construction of a multi-dimensional "codon space" for DNA sequence analysis.
    • Utilizing cluster analysis to group sequences based on base composition.
    • Plotting DNA sequences within the codon space to visualize base composition variations.

    Main Results:

    • DNA base composition is highly nonrandom across codon positions.
    • A strong correlation exists between base composition and organism type.
    • Primitive organisms display higher Adenine (A) or Thymine (T) content in second and third codon positions.
    • Increasing evolutionary complexity correlates with a shift towards higher Guanine (G) and Cytosine (C) content.

    Conclusions:

    • Codon space analysis reveals evolutionary trends in DNA base composition.
    • Base composition patterns serve as a molecular marker for evolutionary progression.
    • Further data can elucidate finer structures within these evolutionary trends.

    Related Experiment Videos