Striatonigral degeneration

Striatonigral degeneration is a relatively uncommon form of parkinsonism. It is clinically characterized by greater debility and a relatively rapid course, often with other superimposed extrapyramidal signs and a poor response to L-dopa. Pathologically it si a multi-system degeneration of the central nervous system, dominated by atrophy of the neostriatum with striking putaminal pigmentation. The clinical and pathological features of this condition are illustrated with a case report and the entity as a nosologic problem is discussed in the light of a review of the literature. The pathogenesis of this condition and its position among the degenerative disorders of the nervous system remain unelucidated.