Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Differential response to cholinergic stimulation in psychogenitically selected rat lines.

J R Martin, P Driscoll, C Gentsch

    Psychopharmacology
    |January 1, 1984
    PubMed
    Summary

    Roman Low-Avoidance (RLA/Verh) rats show stronger responses to oxotremorine, a muscarinic agonist, compared to Roman High-Avoidance (RHA/Verh) rats. Cholinergic antagonists block these effects, suggesting differences in cholinergic neurotransmission.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Correction to: Direct oral anticoagulants for the treatment of venous thromboembolism in patients with active malignancy: a systematic review and meta-analysis.

    Journal of thrombosis and thrombolysis·2018
    Same author

    Prior bariatric surgery may decrease the rate of re-operation and revision following total hip arthroplasty.

    The bone & joint journal·2016
    Same author

    Increase in sensitivity of the baroreceptor reflex following microinjection of carbachol into the posterior hypothalamic nucleus of awake rats.

    Autonomic & autacoid pharmacology·2016
    Same author

    Bariatric surgery does not improve outcomes in patients undergoing primary total knee arthroplasty.

    The bone & joint journal·2015
    Same author

    Duffy blood group phenotype-genotype correlations using high-resolution melting analysis PCR and microarray reveal complex cases including a new null FY*A allele: the role for sequencing in genotyping algorithms.

    Vox sanguinis·2015
    Same author

    Guidelines for chest drain insertion may not prevent damage to abdominal viscera.

    Emergency medicine journal : EMJ·2014

    Area of Science:

    • Neuroscience
    • Behavioral Genetics
    • Pharmacology

    Background:

    • Two rat lines, Roman Low-Avoidance (RLA/Verh) and Roman High-Avoidance (RHA/Verh), were selected for extreme differences in shuttle box avoidance behavior.
    • These lines are used to study the neurobiological underpinnings of avoidance behavior and related physiological responses.

    Purpose of the Study:

    • To investigate the effects of the muscarinic cholinergic agonist oxotremorine on avoidance behavior and associated physiological responses in RLA/Verh and RHA/Verh rats.
    • To explore the role of central and peripheral cholinergic systems in mediating these responses using specific cholinergic antagonists.

    Main Methods:

    • Male and female rats from RLA/Verh and RHA/Verh lines were treated with oxotremorine to assess tremor, salivation, chromodacryorrhea, and hypothermia.

    Related Experiment Videos

  • Subsequent experiments involved pre-treatment with cholinergic antagonists (scopolamine and methscopolamine) to block or reduce oxotremorine-induced effects.

    • Main Results:

    • RLA/Verh rats exhibited significantly greater oxotremorine-induced tremor, chromodacryorrhea, and hypothermia than RHA/Verh rats.
    • Females showed a stronger chromodacryorrhea response to oxotremorine than males.
    • Scopolamine and methscopolamine effectively blocked or reduced oxotremorine-induced responses, indicating the involvement of cholinergic pathways.
    • Hypothermia was reduced by scopolamine in RLA/Verh rats.

    Conclusions:

    • Genetic differences between RLA/Verh and RHA/Verh rats influence their sensitivity to muscarinic cholinergic stimulation.
    • Cholinergic neurotransmission plays a critical role in mediating oxotremorine-induced physiological responses, with potential involvement of both central and peripheral systems.
    • Observed differences may stem from variations in cholinergic neurotransmitter function or other neurochemical systems, rather than muscarinic receptor density.