[Use of purine derivatives for normalizing the hypothalamic function of rats subjected to gamma-neutron irradiation]

In this work, the authors have made an attempt to correct pharmacologically the disorders in the regulatory function of hypothalamus caused by gamma/neutron-irradiation. For this purpose purine derivatives, ethymisol and meradin, were used. These preparations were effective in correcting fully or partially the postirradiation shifts in the balance between the hypothalamus mediators, catecholamines, and their biosynthetic precursor, dioxyphenylalanine (DOPA). In addition, meradin increased the firmness of the bone regenerator in the traumatized extremity of the animal.