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Immunoglobulin abnormalities in malignant non-Hodgkin's lymphoma
Scandinavian Journal of Haematology
|August 1, 1984
Summary
This study found that 24% of patients with chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma (NHL) had monoclonal immunoglobulins (Ig). The presence of monoclonal gammopathy in NHL indicates the differentiation stage of the malignant B-cell clone.
Area of Science:
- Hematology
- Immunology
- Oncology
Background:
- Monoclonal gammopathy is the presence of abnormal proteins in the blood.
- Non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukemia (CLL) are types of B-cell malignancies.
Purpose of the Study:
- To investigate the association between monoclonal gammopathy and B-cell lymphomas.
- To determine the incidence of monoclonal immunoglobulins (Ig) in patients with CLL and NHL.
Main Methods:
- Studied 100 untreated patients with CLL and B-cell NHL.
- Classified lymphomas using Lukes & Collins criteria.
- Assessed the presence and type of monoclonal immunoglobulins (Ig).
Main Results:
- Overall incidence of monoclonal Ig was 24% in the studied cohort.
- Highest incidence (57%) observed in plasmacytoid lymphocytic lymphoma.
- Lowest incidence (7.9%) found in CLL cases, with IgM being the predominant monoclonal Ig class.
Conclusions:
- Monoclonal gammopathy in NHL correlates with the differentiation and maturation stage of the malignant B-cell clone.
- Findings suggest a link between B-cell maturation and the development of monoclonal gammopathy in these malignancies.