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Human pharmacologic trials with iohexol.

T Aakhus, K Dahlström, D D Shaw

    Acta Radiologica. Supplementum
    |January 1, 1983
    PubMed
    Summary
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    Iohexol injections were well tolerated in volunteers across various doses. This non-ionic contrast medium was safely excreted unchanged, indicating its suitability for clinical trials.

    Area of Science:

    • Radiology
    • Pharmacology
    • Clinical Trials

    Background:

    • Iohexol is a non-ionic contrast medium.
    • Safety and tolerability are crucial for new contrast agents.

    Purpose of the Study:

    • To evaluate the safety and tolerability of iohexol in human volunteers.
    • To assess the excretion profile of iohexol.

    Main Methods:

    • Intravenous injections of iohexol administered to two series of volunteers (20 in 1980, 16 in 1982).
    • Doses ranged from 125 to 1500 mg iodine/kg body weight.
    • Excretion of iohexol was monitored.

    Main Results:

    • Iohexol injections were well tolerated across all tested doses.
    • The contrast medium was completely excreted in its unchanged form.

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  • No adverse events were reported.

    • Conclusions:

    • Iohexol demonstrates a favorable safety profile in human subjects.
    • Complete and unchanged excretion supports its use as a safe contrast agent.
    • Results support the progression of iohexol into clinical trials.