Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Research on BCG vaccination.

H G ten Dam

    Advances in Tuberculosis Research. Fortschritte Der Tuberkuloseforschung. Progres De L'Exploration De La Tuberculose
    |January 1, 1984
    PubMed
    Summary

    Bacille Calmette-Guérin (BCG) vaccination for tuberculosis shows varied effectiveness. Further evaluation is needed, especially for children, due to challenges in traditional trial methods.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Annual risk of tuberculous infection. 1988.

    Bulletin of the World Health Organization·2002
    Same author

    Preventive tuberculosis chemotherapy in HIV infection: a priority for study.

    AIDS (London, England)·1992
    Same author

    First experience with BCG discontinuation in Europe. BCG vaccination and HIV infection.

    Bulletin of the International Union against Tuberculosis and Lung Disease·1990
    Same author

    Tuberculosis control in refugee settlements.

    Tubercle·1989
    Same author

    Guidelines for estimating the risks of tuberculous infection from tuberculin test results in a representative sample of children.

    Bulletin of the International Union against Tuberculosis and Lung Disease·1989
    Same author

    Evaluation of the effectiveness of BCG vaccination using the case-control method in Buenos Aires, Argentina.

    International journal of epidemiology·1988

    Area of Science:

    • Immunology
    • Public Health
    • Epidemiology

    Background:

    • Bacille Calmette-Guérin (BCG) vaccination is a cornerstone of global tuberculosis control, particularly for children.
    • Contradictory findings on BCG effectiveness necessitate further investigation.
    • Previous large-scale trials indicated no protection against adult bacillary tuberculosis.

    Purpose of the Study:

    • To expedite the evaluation of BCG vaccination effectiveness in children.
    • To address challenges in conducting classical community trials for tuberculosis interventions.
    • To clarify observed variations in BCG vaccine protection.

    Main Methods:

    • A comprehensive evaluation program was formulated, acknowledging limitations of traditional community trials.
    • Retrospective studies, when integrated into a broader program, may offer valuable insights.
    • Proposed approach involves active follow-up of child contacts of new tuberculosis cases for retrospective and potentially prospective evaluation.

    Main Results:

    • Early results from a South Indian trial suggested BCG provided no protection against adult bacillary tuberculosis.
    • Scientific groups acknowledged the validity of trial results but questioned their general applicability.
    • The need for continued BCG vaccination, especially in children, was emphasized pending further evaluation.

    Conclusions:

    • Despite challenges, BCG vaccination, particularly for young children, should continue.
    • Comprehensive evaluation programs are essential to determine BCG effectiveness and understand protection variations.
    • Innovative study designs, such as contact tracing, are proposed to efficiently assess BCG's protective effect in children.

    Related Experiment Videos