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Published on: January 2, 2017
Artefactual decrease in total protein concentration in patients with monoclonal gammopathies: a method-dependent
Clinical Biochemistry
|August 1, 1984
Abstract:
We found total protein estimates in patients with monoclonal gammopathies to be erroneously low when using the Cobas-Bio centrifugal analyzer. This problem occurred only when a serum-water blank was used. This probably results from the precipitation of these proteins under conditions of low ionic strength resulting in high blank readings. The problem can be avoided if a serum-saline blank is used.

