Induction of human gamma interferon by Sarcophaga peregrina humoral lectin
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Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
Published on: March 2, 2014
FEBS Letters
|October 1, 1984
Abstract:
Humoral lectin isolated from the hemolymph of injured Sarcophaga peregrina (flesh-fly) larvae was found to activate human peripheral blood cells to produce interferon activity. This interferon was inactivated by dialysis against a solution of pH 2.0 and by heat treatment at 56 degrees C for 30 min, indicating that it was a gamma interferon. The role of this lectin in the defence mechanism is discussed from the viewpoint of comparative immunology.
