Osteogenic activity of antibiotic-supplemented bone allografts in the guinea pig

This study evaluated the osteogenic potential of bone allografts supplemented with up to 1000 times the minimum inhibitory concentration of cephalothin and tobramycin effective against Staphylococcus aureus and Pseudomonas aureus. Mineralized and demineralized bone allografts with and without antibiotics were compared in calvarial defects of guinea pigs. Strontium-85 uptake and histologic evaluation indicated there was no significant difference in osteogeneic activity between nonantibiotic-supplemented allografts and antibiotic-supplemented allografts.