[Toxicological studies on a new cephamycin, MT-141. I. Its acute toxicities in mice and rats]

Acute toxicities of MT-141 were studied in mice and rats to obtain the following results. LD50 value of MT-141 by i.v. administration was 6,100 mg/kg for male mice and 5,200 mg/kg for female mice. The LD50 value by i.m. administration was 8,200 mg/kg for the males and 8,600 mg/kg for the females, respectively. The mice administered with a lethal dose of MT-141 showed abnormal syndromes such as decreased spontaneous movement, decreased rate of respiration, ataxic gait, sedative state and loss of righting reflex, followed by a decrease of body weight. Gross inspection revealed no remarkable change in the organs and tissues of mice after a treatment with a lethal dose of MT-141. LD50 value of this compound was 6,600 mg/kg for male rats and 5,700 mg/kg for female rats by i.v. administration, 8,600 mg/kg for the males and 8,550 mg/kg for the females by i.p. administration, 9,600 mg/kg for the males and 9,700 mg/kg for the females by i.m. administration and more than 15,000 mg/kg for both sexes by s.c. or p.o. administration, respectively. The rats given a lethal dose of MT-141 showed abnormal syndromes such as stepping gait, face-down position, decreased rate of respiration, ataxic gait, decreased spontaneous movement and loss of righting reflex, followed by a decrease of body weight. The rats exhibited stretching behavior when given MT-141 through i.p. route and manifested vocalization when given it through s.c. and i.m. routes. The results of gross inspection and histopathological observation suggested that high doses of MT-141 induced slight renal toxicity in rats.(ABSTRACT TRUNCATED AT 250 WORDS)