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Herpes oesophagitis. II. Electron microscopical findings
Virchows Archiv. A, Pathological Anatomy and Histopathology
|January 1, 1984
Summary
Herpes viruses were clearly identified in esophageal biopsy and autopsy samples, showing various replication stages. Characteristic cellular changes, like multinuclear giant cells, indicate late-stage herpes esophagitis.
Area of Science:
- Pathology
- Virology
- Gastroenterology
Background:
- Herpes esophagitis is an infection of the esophagus caused by herpes simplex virus.
- Diagnosis often relies on clinical presentation and endoscopic findings, but histological confirmation is crucial.
Purpose of the Study:
- To demonstrate the presence and characteristics of herpes viruses in esophageal tissue.
- To identify characteristic cytopathological changes associated with herpes esophagitis.
Main Methods:
- Examination of ultra-thin sections from routine biopsy specimens and cytological smears.
- Analysis of one autopsy case with suspected herpes esophagitis.
Main Results:
- Herpes viruses were clearly identified in all examined cases.
- Infected epithelial cells showed various stages of virus replication.
- Characteristic late-stage changes included ground-glass nuclei and multinuclear giant cells at ulcer edges.
Conclusions:
- Histopathological examination of esophageal tissue is effective for diagnosing herpes esophagitis.
- Specific cytopathological findings aid in identifying the late ulcerative stage of the infection.