Functional development of the visual system in normal and protein deprived rats. I. Persistent changes in...

During an investigation focused on development of visual evoked responses (VER) in normal and protein deprived rats indications of persisting latency differences were found. Since such differences are in variance with previous reports special attention was paid to compare control and protein deprived adult rats. Protein deprivation was induced by feeding rats a diet with 50% reduction in protein content compared with control rat diet from two weeks before onset of gestation until examination. Dependence on experimental variables of latencies and complexity of the VER illustrated the need of a well defined experimental situation. Adult protein deprived rats showed significantly longer latencies to onset and to the first three peaks of the VER and an altered complexity of the response. It is suggested that the observed alterations result from effects of the protein deprivation on early brain development since this and previous studies have shown similar alterations in developing young rats. The divergence in findings between the present and previous reports may be explained by differences in degree of malnutrition and in other experimental conditions.