[Comparative study of the vasoreactivity of isolated human cortical and juxtamedullary glomeruli using verapamil and...

The purpose of the present study was to compare the area variations of human cortical and juxtamedullary glomeruli after incubation with verapamil and dopamine. The glomeruli were isolated by sieving; areas were measured by a video analyser. The surface of the cortical glomeruli increases largely with verapamil (+14,3%) and dopamine (+11,5%). But, the area of the juxtamedullary glomeruli remains unchanged in the same experimental conditions. Evidence of such a vasoreactivity difference between cortical and juxtamedullary glomeruli will permit a better understanding in the regulation of renal haemodynamics.