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Related Experiment Videos

Morphine infusion after pediatric cardiac surgery.

A M Lynn, K E Opheim, D C Tyler

    Critical Care Medicine
    |October 1, 1984
    PubMed
    Summary

    Continuous IV morphine sulfate infusion effectively managed pain in pediatric cardiac surgery patients. It did not impede spontaneous breathing, with pain relief achieved at serum levels above 12 ng/ml.

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    Anesthesia and analgesia·2001

    Area of Science:

    • Pediatric Anesthesiology
    • Critical Care Medicine
    • Pharmacology

    Background:

    • Post-cardiac surgery pain management in children is crucial.
    • Opioid analgesics like morphine sulfate are commonly used.
    • Ensuring respiratory function during and after mechanical ventilation is a priority.

    Purpose of the Study:

    • To evaluate the efficacy and safety of continuous intravenous morphine sulfate infusion in pediatric cardiac surgery patients.
    • To determine the relationship between serum morphine levels and respiratory parameters (PaCO2).
    • To assess pain relief at specific serum morphine concentrations.

    Main Methods:

    • A cohort of 44 children undergoing cardiac surgery received continuous IV morphine sulfate (10-30 µg/kg/h).
    • Serum morphine levels were monitored.
    • PaCO2 levels were assessed during weaning and spontaneous ventilation.
    • Pain scores were obtained from 12 older children.

    Main Results:

    • Serum morphine levels below 30 ng/ml were not associated with elevated PaCO2 during ventilation weaning and spontaneous breathing.
    • Morphine infusion did not interfere with spontaneous ventilation in 35 of 40 patients.
    • Pain was effectively relieved in 12 children at serum morphine levels >12 ng/ml.

    Conclusions:

    • Continuous IV morphine sulfate is safe and effective for pain management in pediatric cardiac surgery.
    • Therapeutic serum morphine levels can be maintained without compromising respiratory drive.
    • Morphine sulfate facilitates pain control and supports respiratory weaning in this population.

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