Related Experiment Videos
[Toxicological studies on a new cephamycin, MT-141. X. Its perinatal and postnatal test in rats]
Insights
MT-141 demonstrated no adverse effects in pregnant and lactating rats, even at high doses. This perinatal and postnatal study found no impact on maternal health or offspring development, indicating safety.
Area of Science:
- Pharmacology
- Toxicology
- Reproductive Science
Context:
- Perinatal and postnatal studies are crucial for evaluating drug safety in vulnerable populations.
- SD rats are a common model for assessing developmental and reproductive toxicity.
Purpose:
- To evaluate the perinatal and postnatal effects of MT-141 in Sprague-Dawley (SD) rats.
- To determine the maximal "no effective" dose of MT-141 in dams and their offspring.
Summary:
- Dams were administered MT-141 (400, 800, 1,600 mg/kg/day) from gestation day 17 to postnatal day 21.
- No significant adverse effects were observed on maternal body weight, food, or water intake.
- MT-141 did not affect reproductive parameters, F1 offspring development, physiology, behavior, fertility, or cause fetal defects.
Impact:
- Establishes a high maximal "no effective" dose for MT-141, exceeding 1,600 mg/kg/day.
- Provides critical safety data for MT-141 during the perinatal and postnatal periods.
- Supports the potential use of MT-141 with a favorable safety profile in reproductive contexts.
Abstract:
A perinatal and postnatal study of MT-141 was performed in SD rats. The dams were administered intramuscularly (i.m.) with MT-141 at the dose levels of 400, 800 and 1,600 mg/kg/day from the day 17 of gestation until the day 21 post delivery. The results are summarized as follows. No significant adverse effects of MT-141 were observed on the body weight gain, food consumption and water intake in dams of all groups treated with the drug during the perinatal and postnatal period. MT-141 did not change parameters of reproductive study in birth, development, physiological function and behavior of F1 rat. This compound had no effect on the fertility in F1 rats and also did not caused significant defects in the external appearance, viscera and skeleton of fetuses from dams (F1). It is concluded from these results that the maximal "no effective" dose of MT-141 is above 1,600 mg/kg/day i.m. for dams and the offsprings.