A dramatic behavioral response to thyrotropin-releasing hormone following low-dose neuroleptics

A dramatic improvement in mood and behavior after TRH occurred during treatment with low-dose neuroleptics in a patient with major depression and borderline personality disorder. This response was observed during both open and double-blind trials. The administration of TRH alone or with higher dosages of neuroleptics, was ineffective. Twenty other patients with major depression, including several with borderline personality disorder, were studied in an identical design but did not show similar improvement.