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Related Experiment Videos

Phencyclidine-analogue self-injection by the baboon.

S E Lukas, R R Griffiths, J V Brady

    Psychopharmacology
    |January 1, 1984
    PubMed
    Summary

    This study shows phencyclidine (PCP) and its analogues have similar abuse potential in baboons, with varying potencies. Dose influenced injection timing, with higher doses leading to more uniform daily distribution.

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    Area of Science:

    • Pharmacology
    • Neuroscience
    • Behavioral Science

    Background:

    • Phencyclidine (PCP) and its analogues are substances of abuse.
    • Understanding their comparative abuse potential is crucial for harm reduction.

    Purpose of the Study:

    • To compare the self-injection potencies and abuse potential of PCP and four analogues in baboons.
    • To investigate the influence of dose on the timing of drug injections.

    Main Methods:

    • Baboons self-injected phencyclidine hydrochloride (PCP) and analogues via intravenous routes under a fixed-ratio schedule.
    • Drug substitution for cocaine was performed, with 15-day test periods for each compound.
    • Injection timing and food intake were monitored.

    Main Results:

    • All tested compounds (PCP, NMPCA, TCPY, NNBPCA, ketamine) maintained self-injection behavior, indicating abuse liability.
    • Relative potencies were determined: PCP > NMPCA = TCPY > NNBPCA > ketamine.
    • Higher doses led to more uniform injection distribution throughout the day, unlike lower doses concentrated during daylight hours.

    Conclusions:

    • PCP and its analogues exhibit comparable abuse potential in baboons, with significant differences in potency.
    • Dose-dependent alterations in injection patterns suggest complex behavioral pharmacology.
    • These findings contribute to understanding the neurobiological basis of stimulant and dissociative drug abuse.

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