A non-haemagglutinating isolate of mink enteritis virus

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Propagating and Detecting an Infectious Molecular Clone of Maedi-visna Virus that Expresses Green Fluorescent Protein
08:49

Propagating and Detecting an Infectious Molecular Clone of Maedi-visna Virus that Expresses Green Fluorescent Protein

Published on: October 9, 2011

E Rivera, B Sundquist

    Veterinary Microbiology
    |August 1, 1984
    PubMed

    Insights

    Researchers identified a novel mink enteritis virus (MEV) strain, MEV-S, from affected mink. This strain lacks the typical haemagglutinating activity seen in other MEV strains.

    Area of Science:

    • Veterinary Virology
    • Infectious Diseases of Animals

    Background:

    • Mink enteritis is a significant disease in mink farming.
    • Mink enteritis virus (MEV) is the causative agent.
    • Characterization of MEV strains is crucial for disease control.

    Purpose of the Study:

    • To isolate and identify the virus responsible for a recent outbreak of mink enteritis.
    • To characterize the biological and physical properties of the isolated virus.
    • To compare the isolate with known MEV strains.

    Main Methods:

    • Virus isolation from diseased mink.
    • Serological testing for identification.
    • Determination of virus density using Cesium Chloride (CsCl) gradient centrifugation.
    • Electron microscopy for morphology and size determination.
    • Haemagglutination (HA) assays using various red blood cells (RBCs), temperatures, and pH levels.

    Main Results:

    • A virus, designated MEV-S, was successfully isolated from mink exhibiting enteritis.
    • MEV-S was identified as a mink enteritis virus based on serological, density (1.415 g cm-3), and morphological (20 nm diameter) characteristics.
    • MEV-S exhibited a lack of haemagglutinating (HA) activity with swine, horse, bovine, and rhesus monkey red blood cells under various conditions.

    Conclusions:

    • The isolated virus, MEV-S, is a distinct strain of mink enteritis virus.
    • The absence of HA activity differentiates MEV-S from previously described MEV strains.
    • Further studies are needed to understand the implications of this altered characteristic for MEV pathogenesis and epidemiology.

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