[Therapeutic effectiveness of the transdermal system with nitroglycerin in comparison with nifedipine]

In 12 patients with coronary artery disease 10 cm3 TTS-Nitroderm with 2 X 20 mg Nifedipine were compared. Both substances lowered the number of anginal attacks and the intake of nitroglycerin capsules. Nifedipine pronounced the decrease of afterload as demonstrated by the pressure-rate product. TTS-Nitroglycerin decreased preload and showed a good efficacy. The therapeutic effect was unchanged within the 14 days of observation. By this system the continuous application of nitroglycerin is another therapeutic form of practicable long-term therapy.