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Related Experiment Videos

[Experiences with levonorgestrel in postcoital contraception].

E Canzler, H J Ahrendt, S Ahrendt

    Zentralblatt Fur Gynakologie
    |January 1, 1984
    PubMed
    Summary
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    Levonorgestrel is not a reliable method for routine hormonal contraception due to low efficacy and menstrual irregularities. It should only be used occasionally after unprotected sex in specific circumstances.

    Area of Science:

    • Reproductive Endocrinology
    • Pharmacology

    Context:

    • Postcoital contraception aims to prevent pregnancy after unprotected intercourse.
    • Levonorgestrel is a synthetic progestogen used in emergency contraception.

    Purpose:

    • To evaluate the efficacy and side effects of levonorgestrel as a postcoital contraceptive.
    • To assess the impact of different dosages and administration frequencies on contraceptive outcomes.

    Summary:

    • Two dosages of levonorgestrel (0.4 mg and 0.75 mg) were tested for postcoital contraception.
    • Pregnancy rates were 8.3 (0.4 mg) and 5.3 (corrected, 0.75 mg) Pearl's index.
    • High incidence of menstrual irregularities (break-through bleeding, oligomenorrhea) observed in 84.4% and 88.9% of users.
    • Mechanism of action involves cervical and endometrial factors, with ovulation often still occurring.

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    Impact:

    • Levonorgestrel is deemed unreliable for routine hormonal contraception.
    • Significant menstrual irregularities and insufficient efficacy limit its use.
    • Recommended only for occasional use after unprotected intercourse, particularly for women with low intercourse frequency or during periods of reduced fertility.