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Effect of danazol on thyroid function in postmenopausal women.
Acta Obstetricia Et Gynecologica Scandinavica. Supplement
|January 1, 1984
Summary
Danazol treatment reduces thyroxin-binding globulin (TBG) levels, impacting thyroid function tests. This effect is likely direct and independent of estrogen changes, with no observed clinical impact on thyroid hormone target organs.
Area of Science:
- Endocrinology
- Pharmacology
Background:
- Danazol is known to decrease serum thyroxin-binding globulin (TBG) concentrations.
- The mechanism of TBG reduction by danazol, whether direct or indirect via estrogen suppression, requires clarification.
Purpose of the Study:
- To investigate the direct effect of danazol on TBG production.
- To determine if danazol's effect on TBG is independent of its impact on serum estrogen levels.
Main Methods:
- Twelve postmenopausal female volunteers received danazol (400, 600, or 800 mg/day).
- Serum concentrations of TBG, TSH, total T4, total T3, and free T4/T3 fractions were measured at baseline, 2, and 4 weeks.
Main Results:
- Danazol significantly decreased serum TBG, total T4, and total T3 concentrations.
- TSH and free T4 levels showed minimal changes, while free T3 decreased transiently.
- These effects were consistent across all danazol dosages and independent of estrogen levels.
Conclusions:
- Danazol directly reduces TBG concentration, independent of its effect on estrogen.
- Danazol treatment alters thyroid function tests by lowering TBG.
- No clinical evidence suggests impaired thyroid hormone action on target organs.