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Related Experiment Videos

C reactive protein concentrations during long distance running.

A F Strachan, T D Noakes, G Kotzenberg

    British Medical Journal (Clinical Research Ed.)
    |November 10, 1984
    PubMed
    Summary

    Long distance running triggers an acute phase response, indicated by elevated C-reactive protein (CRP) levels. Higher CRP levels after ultramarathons may mimic myocardial infarction, highlighting the need for baseline CRP in runners.

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    Area of Science:

    • Sports Medicine
    • Biochemistry
    • Clinical Physiology

    Background:

    • Endurance running, particularly ultramarathons, can induce physiological stress.
    • The acute phase response, marked by C-reactive protein (CRP) elevation, is a key indicator of inflammation.
    • Distinguishing exercise-induced CRP changes from pathological conditions like myocardial infarction is clinically relevant.

    Purpose of the Study:

    • To investigate the relationship between running distance and the acute phase response in long-distance runners.
    • To establish reference ranges for serum C-reactive protein (CRP) concentrations based on race distance.
    • To assess the potential of CRP levels to aid in diagnosing myocardial infarction in runners.

    Main Methods:

    • Serum CRP concentrations were measured in long-distance runners participating in events from 15 km to 88 km.

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  • CRP levels were analyzed in relation to race distance and athlete training status.
  • The effect of indomethacin on CRP elevation after an 88 km ultramarathon was examined.

    • Main Results:

    • A distance-dependent increase in serum CRP concentrations was observed with longer running distances.
    • Trained athletes showed minimal CRP rise after races under 21 km.
    • CRP levels after an 88 km ultramarathon were comparable to those seen in patients with myocardial infarction.
    • Indomethacin did not alter the CRP increase following the ultramarathon.

    Conclusions:

    • Serum CRP concentrations demonstrate a clear relationship with running distance in endurance athletes.
    • Established CRP levels for specific race distances may assist in differentiating exercise-induced responses from myocardial infarction.
    • Measuring the acute phase response in untrained individuals undertaking shorter runs is recommended for comparative data.