Effect of tissue selection on melanization of MI hamster melanoma

Selection of the most melanized tissue of the slightly melanotic MI melanoma in hamster resulted in an origin of a new highly melanotic tumor line. It differed from the parental MI melanoma in the 5-fold higher melanin content, but its tyrosinase activity, growth rate and histological structure remained unchanged. Selection of the least melanotic tissue of the MI melanoma did not give positive results.