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Related Experiment Videos

Synapsin I in nerve terminals: selective association with small synaptic vesicles.

F Navone, P Greengard, P De Camilli

    Science (New York, N.Y.)
    |December 7, 1984
    PubMed
    Summary

    Synapsin I in the brain preferentially binds to small synaptic vesicles, not large dense-core vesicles. This finding explains why synapsin I is exclusive to neurons, differentiating them from endocrine cells.

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    Synaptojanin 1 contributes to maintaining the stability of GABAergic transmission in primary cultures of cortical neurons.

    The Journal of neuroscience : the official journal of the Society for Neuroscience·2001

    Area of Science:

    • Neurobiology
    • Cell Biology
    • Neurochemistry

    Background:

    • Synapsin I is a neuron-specific phosphoprotein.
    • Synaptic vesicles and dense-core vesicles have distinct roles in neuronal and endocrine secretion.

    Purpose of the Study:

    • To investigate the specific localization of synapsin I within different types of vesicles in the bovine hypothalamus.
    • To elucidate the molecular basis for synapsin I's exclusive presence in neurons.

    Main Methods:

    • Immunocytochemistry was employed to detect synapsin I.
    • Vesicles were characterized by size (small synaptic vesicles: 40-60 nm; large dense-core vesicles: >60 nm).

    Main Results:

    • Synapsin I was found to be preferentially, and possibly exclusively, associated with small synaptic vesicles.
    • No association was observed between synapsin I and large dense-core vesicles.

    Conclusions:

    • Synapsin I's preferential association with small synaptic vesicles supports its role in neuronal synaptic transmission.
    • This localization explains the exclusive presence of synapsin I in neurons, distinguishing them from endocrine cells which utilize large dense-core vesicles.

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