Effect of C 21 524-Su (pirprofen) on spontaneous osteoarthrosis in the mouse

Mice of the C57 Black strain, aged 11-12 weeks, were treated once daily on 5 days a week for 4 months with C 21 524-Su (pirprofen) in doses of 10 and 30 mg/kg p.o. In this genetically predisposed strain of mice, increases in the incidence of gonarthrosis have been observed after the administration of certain anti-inflammatory agents such as acetylsalicylic acid. Radiography and in particular exact histological examination of the knee joints revealed, however, that neither the overall incidence nor the severity of osteoarthrosis was greater in the mice treated with C 21 524-Su than in the controls. On the contrary, in the treated animals there was a tendency for the incidence and the intensity of gonarthrosis to be lower.