Acute hemolytic anemia induced by a pyrazolonic drug in a child with glucose-6-phosphate dehydrogenase deficiency
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Published on: January 2, 2013
Acta Haematologica
|January 1, 1984
Insights
A pyrazolone drug triggered severe hemolytic anemia in a child lacking glucose-6-phosphate dehydrogenase (G6PD) enzyme activity. This drug
Area of Science:
- Biochemistry
- Pediatrics
- Hematology
Background:
- Drug-induced hemolytic anemia is a significant clinical concern.
- Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an inherited condition.
- Pyrazolone drugs are known for various adverse effects, but hemolytic anemia is not commonly reported.
Observation:
- A 36-month-old child developed severe hemolytic anemia following pyrazolone drug administration.
- The patient exhibited absent erythrocyte glucose-6-phosphate dehydrogenase (G6PD) activity.
- The mother and maternal grandmother showed intermediate G6PD levels and erythrocyte mosaicism.
Findings:
- The study identifies a potential link between pyrazolone drugs and hemolytic anemia in G6PD-deficient individuals.
- Erythrocyte mosaicism and Heinz bodies were observed during the hemolytic crisis.
- This is the first reported case of pyrazolone-induced hemolytic anemia in the medical literature.
Implications:
- Highlights the importance of screening for G6PD deficiency before administering pyrazolone drugs, especially in pediatric cases.
- Suggests that pyrazolone drugs may act as a trigger for hemolysis in susceptible individuals with G6PD deficiency.
- Underscores the need for further investigation into the hemolytic potential of pyrazolone drugs in G6PD-deficient populations.
Abstract:
In a 36-month-old child a severe hemolytic anemia occurred after the administration of a pyrazolonic drug. Erythrocyte glucose-6-phosphate dehydrogenase activity was absent in the patient. Intermediate enzymatic levels were demonstrated in the mother and in the maternal grand-mother with a corresponding erythrocyte mosaicism at the methemoglobin elution test. Some cells showed Heinz bodies and peculiar changes in the morphology in the initial phase of the crisis. There is no mention in the literature of a hemolytic action of this drug.
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