Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dose-response curve for the ergotamine-induced decrease of peripheral systolic blood pressure in man.

P Tfelt-Hansen, P M Manniche

    Acta Pharmacologica Et Toxicologica
    |September 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Interictal "patchy" regional cerebral blood flow patterns in migraine patients. A single photon emission computerized tomographic study.

    European journal of neurology·2013
    Same author

    CGRP receptor antagonist olcegepant (BIBN4096BS) does not prevent glyceryl trinitrate-induced migraine.

    Cephalalgia : an international journal of headache·2010
    Same author

    Posterior hypoperfusion in migraine without aura?

    Cephalalgia : an international journal of headache·2010
    Same author

    Subjective and objective effects of the novel triple reuptake inhibitor tesofensine in recreational stimulant users.

    Clinical pharmacology and therapeutics·2010
    Same author

    Nitroglycerin provocation in normal subjects is not a useful human migraine model?

    Cephalalgia : an international journal of headache·2009
    Same author

    Guidelines for controlled trials of drugs in tension-type headache: second edition.

    Cephalalgia : an international journal of headache·2009

    Ergotamine tartrate administration caused a temporary rise in arm blood pressure. The study found that toe-arm systolic pressure gradients decreased in a dose-dependent manner, useful for comparing ergotamine tartrate doses.

    Area of Science:

    • Pharmacology
    • Cardiovascular Physiology

    Background:

    • Ergotamine tartrate is a medication used for treating migraines.
    • Understanding its cardiovascular effects is crucial for safe and effective use.

    Purpose of the Study:

    • To investigate the dose-dependent cardiovascular effects of intravenous ergotamine tartrate.
    • To evaluate the utility of systolic blood pressure gradients in assessing ergotamine tartrate pharmacodynamics.

    Main Methods:

    • A double-blind, cross-over study involving 5 healthy volunteers.
    • Intravenous administration of varying doses of ergotamine tartrate (0.05-0.5 mg/70kg).
    • Monitoring of arm, ankle, and big toe systolic blood pressures for 6 hours post-administration.

    Main Results:

    Related Experiment Videos

    • A transient, dose-dependent increase in arm systolic blood pressure was observed.
    • No clear dose-response relationship was found for ankle-arm systolic pressure gradients.
    • Toe-arm systolic pressure gradients exhibited a dose-dependent decrease.

    Conclusions:

    • Toe-arm systolic pressure gradients show promise for pharmacodynamic comparisons of ergotamine tartrate.
    • These findings contribute to understanding ergotamine tartrate's cardiovascular impact and optimizing its clinical application.