The Du phenotype, serology, and clinical relevance

In this article, the authors examine the nature of the Du phenomenon through a comprehensive historical review beginning with the initial description of the Du factor in the 1940s. Pertinent developments in serologic testing methods and genetic concepts are described. Evidence of the importance of the Du factor in transfusion and hemolytic disease of the newborn is also presented. Selected articles on the frequency of Du in Caucasian and Negro populations are cited. Finally, the authors review current theoretical concepts concerning the nature of the Du factor, its importance in current transfusion practice and maternal Rh immune globulin administration, and the use of microscopic Du testing as a screening procedure for fetomaternal hemorrhage.