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Related Experiment Videos

Prolactin, amitriptyline, and recovery from depression.

J Lisansky, G A Fava, M T Buckman

    Psychopharmacology
    |January 1, 1984
    PubMed
    Summary

    Spontaneous prolactin levels increased in patients with melancholia after amitriptyline treatment and recovery. Non-recovered patients showed a contrasting decrease in prolactin, suggesting a link between prolactin patterns and treatment outcomes.

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    Area of Science:

    • Neuroendocrinology
    • Psychiatry
    • Pharmacology

    Background:

    • Melancholia is a severe subtype of depression.
    • Altered neuroendocrine function, including prolactin secretion, is observed in depression.

    Purpose of the Study:

    • To investigate spontaneous prolactin secretion patterns in melancholia patients before and after amitriptyline treatment.
    • To explore the relationship between prolactin levels and treatment response.

    Main Methods:

    • 15-minute interval blood sampling over 5 hours.
    • Analysis of plasma prolactin levels in 13 melancholia patients.
    • Comparison of prolactin patterns during illness and after recovery with amitriptyline.

    Main Results:

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  • Significantly higher plasma prolactin levels were observed at most sampling points post-recovery compared to during illness.
  • One patient who did not recover exhibited an inverse prolactin trend.

    • Conclusions:

    • Amitriptyline treatment and recovery in melancholia are associated with increased spontaneous prolactin secretion.
    • Prolactin level changes may serve as a biomarker for treatment response in melancholia.